In vitro neutralization of il-6 receptor exacerbates damage to intestinal epithelial cells during mycobacterium avium paratuberculosis infection

HIGHLIGHTS

• What: The authors demonstrate the detrimental effects of blocking IL-6 signaling during MAP infection on intestinal epithelial integrity and function. The authors present this as the authors compare to the direct damaging Frontiers in Immunology In HT-29 mucin-producing cell line, the authors show a dose-dependent reduction in MUC2 gene_expression (reduction by 34% at 2.5 ng/mL rIL-6, P-value and amp;lt; 0.005, and reduction by 35% at IL-6 and sIL-6R release levels in MAP-infected THP-1 macrophages. In Figure 9, the authors show how rTNFa alone . . .
  

   

  

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