In vitro pharmacokinetic behavior of antiviral 3-amidinophenylalanine derivatives in rat, dog and monkey hepatocytes

HIGHLIGHTS

  • who: Katalin Lu00e1nyi and collaborators from the Department of Food Hygiene, University of Veterinary Medicine, Istvu00e1n utca, Weg, Marburg, Germany have published the research work: In Vitro Pharmacokinetic Behavior of Antiviral 3-Amidinophenylalanine Derivatives in Rat, Dog and Monkey Hepatocytes, in the Journal: Biomedicines 2023, 11, 682. of /2023/
  • what: In this study the depletion rates of the 3amidinophenylalanine (3-APhA)-derived matriptase/TMPRSS2 inhibitors MI-463 MI-472 MI-485 or MI-1900 were determined by LC-MS/MS measurements over a period of 300 min using suspensions of rat dog and cynomolgus monkey . . .

     

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