In vivo stress reporters as early biomarkers of the cellular changes associated with progeria

HIGHLIGHTS

  • who: Inesta-Vaquera and colleagues from the University of Dundee Dundee, UK have published the research: In vivo stress reporters as early biomarkers of the cellular changes associated with progeria, in the Journal: (JOURNAL) of 28/06/2022
  • what: The authors report a time-u00adand tissue-u00adspecific increase in and normal human ageing including accumulation of nuclear enve- oxidative stress/inflammation and DNA damage reporter signals lope defects, progerin accumulation and activation of inflammatory in disease-u00ad relevant cell types before any deleterious phenotype pathways as NF-u00adu03baB . is observed in LmnaG609G heterozygous and homozygous . . .

     

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