HIGHLIGHTS
- who: Jin Hyup Lee from the (UNIVERSITY) have published the Article: Inactivation of NADP+-dependent Isocitrate Dehydrogenase by Peroxynitrite, in the Journal: (JOURNAL)
- how: Inactivation of ICDH by NO in Intact Cells-Because peroxynitrite and SIN-1 readily inactivates ICDH in_vitro the authors examined ICDH activity in U937 a histiocytic lymphoma cell line after treatment with 100 M SIN-1 bolus as a source of peroxynitrite. To evaluate the inactivation of ICDH by peroxynitrite in_vivo the authors examined mitochondrial ICDH activity of liver from ethanolfed rats.
- future: There are several lines of evidence . . .
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