Inactivation of target rna cleavage of a iii-b crispr-cas system induces robust autoimmunity in saccharolobus islandicus

HIGHLIGHTS

• who: Yan Zhang and collaborators from the Henan Engineering Laboratory for Bioconversion Technology of Functional Microbes, College of Life Sciences, Department of Biology, University of Copenhagen, Ole MaalQingdao, China have published the paper: Inactivation of Target RNA Cleavage of a III-B CRISPR-Cas System Induces Robust Autoimmunity in Saccharolobus islandicus, in the Journal: (JOURNAL)
• what: The authors show that generation of a nuclease-dead Cmr4α (dCmr4α) mutant by amino_acid substitution at the active_site induces cell dormancy or cell death in S. islandicus, which is in good agreement with the model.
• how: Since . . .
  

   

  

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