Incomplete folding upon binding mediates cdk4/cyclin d complex activation by tyrosine phosphorylation of inhibitor p27 protein*

HIGHLIGHTS

• who: Li Ou u6b27 u55c9 from the (UNIVERSITY) have published the Article: Incomplete Folding upon Binding Mediates Cdk4/Cyclin D Complex Activation by Tyrosine Phosphorylation of Inhibitor p27 Protein*, in the Journal: (JOURNAL) of August/26,/2011
• what: The authors report the use of circular dichroism (CD), isothermal titration calorimetry (ITC), computational docking, and biochemical assays to characterize and compare the interactions of Cdk4/cyclin D and Cdk2/cyclin A with p27-KID and various p27-KID deletion constructs. The authors propose that p27 has evolved to utilize different combinations of residues within its conserved . . .
  

   

  

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