Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by bh3-mimetics

HIGHLIGHTS

• who: Anna L. Koessinger from the Organotypic adult mouse brain slice culture Orthotopic intracranial and subcutaneous xenografts All mouse experiments were carried out in accordance with the Animals Act , (Scientific Procedures on living animals) and the regulatory guidelines of the EU Directive , under project licences PPL P , and , and ethical review (University of Glasgow)Sample sizes were based on our previous experiences with intracranial and subcutaneous GBM xenografts using the same cell lines. For intracranial xenografts, week old female CD1-nude mice (Charles River, UK) were orthotopically injected with , u00d7 , iRFP-labelled vectorCRISPR and MCL- CRISPR , GSC . . .
  

   

  

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