HIGHLIGHTS
SUMMARY
Islet β-cell apoptosis is the major form of β-cell failure in diabetes (Cnop et_al, 2005; Moin and Butler, 2019). The β-cells lose the characteristics of mature cells and subsequently lose the ability to secrete INS because of gene regulation (Bensellam et_al, 2018; Moin and Butler, 2019). The decrease and dysfunction of β-cells are the key factors that lead to diabetes_mellitus (D`Addio et_al, 2022; Veres et_al, 2019). CD34 is primarily expressed on hematopoietic stem and progenitor cells (Nielsen and McNagny, 2008; Sidney et_al, 2014) as well as on nonhematopoietic cells such as mesenchymal stromal . . .
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