Increased concentrations of fructose 2,6-bisphosphate contribute to the warburg effect in phosphatase and tensin homolog (pten)-deficient cells*

HIGHLIGHTS

• who: Lucía Cordero-Espinoza from the Lucía Cordero-Espinoza and Thilo Hagen, From the Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore Background: PTEN deficiency leads to increased glycolytic flux characteristic of cancer cellsResults: PTEN-deficient cells have high concentrations of fructose, bisphosphate due to protein stabilization of , that results from impaired APC/C-Cdh1-dependent degradation. Conclusions: Elevated fructose, bisphosphate concentrations contribute to the increased rates of glycolysis and proliferation in PTEN-deficient cells. Significance: Fructose, bisphosphate might be a crucial mediator of tumorigenesis in PTEN-deficient . . .
  

   

  

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