HIGHLIGHTS
SUMMARY
As the precursors of antibody-bearing cells, B cells have been highlighted in the AAV pathogenesis by the identification of activated B cells in granulomatous lesions and the efficacy of B cell depletion in treatment of AAV patients. B cells can be subdivided into naïve cell (CD27IgD+), pre-switched memory cell (CD27+IgD+), conventional memory cell (CD27+IgD-), double-negative (DN) memory cell (CD27-IgD-), plasmablast (CD27+CD38hiIgM-), and plasma cell (PC, CD27+CD138+) subsets according to their surface markers. The authors did not find a significant correlation between the frequency of IgD . . .
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