Increased number of t cells and exacerbated inflammatory pathophysiology in a human igg4 knock-in mrl/lpr mouse model

HIGHLIGHTS

• who: Yoshie Gon et al. from the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Japan have published the paper: Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model, in the Journal: PLOS ONE of 10/01/2022
• what: The authors aimed to investigate the function of hIgG4, whose function does not completely match that of mIgG1. The MRL/lpr mouse strain used in this study (MRL/MpJJmsSlc-lpr/lpr) has an elevated lifespan compared to the MRL/MpJ-Faslpr/J . . .
  

   

  

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