HIGHLIGHTS
- who: Kevin C. Ma from the Chan School have published the research work: Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- how: To control for the confounding effect of the 23S rRNA mutations the authors conducted a conditional GWAS by incorporating additional covariates in the linear mixed model encoding the number of copies (ranging from 0 to 4) of the resistanceconferring 23S rRNA substitutions C2611T and A2059G. The authors provided confirmatory evidence that the RplD G70D mutation increases macrolide MICs several . . .
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