Increased risk of hereditary prostate cancer in italian families with hereditary breast and ovarian cancer syndrome harboring mutations in brca and in other susceptibility genes

HIGHLIGHTS

SUMMARY

Prostate cancer (PCa) is a heterogeneous disease, representing one of the major causes of malignancy-related deaths worldwide, with about 1,600,000 cases and 366,000 deaths annually. Hereditary prostate cancer (HPCa) has the highest heritability of any cancer in men, with tumorigenesis occurring due to 2 of 13 the presence of germline mutations transmitted through autosomal dominant inheritance. Patients who harbor mutations in DDR genes, for example, would likely be more sensitive to a treatment regime that includes PARP inhibitors, whereas the mutational status of MMR genes in metastatic patients could predict . . .

 



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