Independent validation of a dysphagia dose response model for the selection of head and neck cancer patients to proton therapy

HIGHLIGHTS

SUMMARY

This study examined dosimetric photon and proton based NTCP parameters differences by internally validating the NTCP model of Lyman-Kutcher-Burman (LKB) using prospective treatment and morbidity data of PT treated prostate cancer patients. The authors highlighted the importance of NTCP models up­ date and external validation due to clinical practice patterns changes as they concluded that dosimetric parameters such as the mean dose to 50 % of the target volume (D50) was different from the typical photonbased LKB NTCP model. Despite the initial goal to externally validate the NTCP dysphagia model using an independent . . .

 



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