Individual behavioral profiling as a translational approach to assess treatment efficacy in an animal model of post-traumatic stress disorder

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SUMMARY

    Address the heterogeneity in treatment response in an animal model of PTSD (Richter-Levin et_al, 2015). Together the evidence suggests that disruption of the E/I homeostasis is one of the major underlying causes of PTSD pathophysiology (Chambers et_al, 1999; Bremner et_al, 2000; Reul and Nutt, 2008; Meyerhoff et_al, 2014; Michels et_al, 2014; Rosso et_al, 2014). Fluoxetine is known to influence E/I balance by altering GABA and glutamate mediated neurotransmission (Fang et_al, 2018; Lazarevic et_al, 2019; Sheth et_al, 2019). Social recognition test Social recognition test measures the social recognition memory of an animal . . .

     

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