Indoleamine 2, 3-dioxygenase 1 mediates survival signals in chronic lymphocytic leukemia via kynurenine/aryl hydrocarbon receptor-mediated mcl1 modulation

HIGHLIGHTS

  • who: Claudio Giacinto Atene from the University of Perugia, Italy have published the paper: Indoleamine 2, 3-Dioxygenase 1 Mediates Survival Signals in Chronic Lymphocytic Leukemia via Kynurenine/Aryl Hydrocarbon Receptor-Mediated MCL1 Modulation, in the Journal: (JOURNAL)
  • how: Data were analyzed using GraphPad Prism 6 (GraphPad Software) or R 3.6.3 software (The R Foundation for Statistical Computing). This result was also confirmed by measuring a decrease in the apoptotic rate after transfection with the IDO1 vector as shown in Supplementary Figure 1A. Summarizing these data showed that the IDO1/Kyn/AHR axis . . .

     

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