HIGHLIGHTS
- who: Alexandra Maria Psaras and colleagues from the School of Pharmacy and, Binghamton University, Binghamton, NY, USA have published the Article: Indoloquinoline-Mediated Targeted Downregulation of KRAS through Selective Stabilization of the Mid-Promoter G-Quadruplex Structure, in the Journal: Genes 2022, 1440 of /2022/
- what: While in the current study, selectivity for KRAS G4mid over G4near and MYC was observed, only a small subset of target G4s were examined and the cytotoxicity across pancreatic cancer cell lines is most likely related to promiscuity of G4 binding and stabilization for compound 9a, as frequently noted . . .
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