Indoxyl sulfate and its potential role in mineralocorticoid receptor transactivation in chronic kidney disease

HIGHLIGHTS

  • What: This study showed that IS is partially responsible for MR activation in CKD, and α-lipoic_acid, an antioxidant agent, inhibited IS-induced potentiation of MR transactivation. The 5/6 Nx group in this study showed decreased plasma aldosterone levels compared with the sham group.
  • Who: Akiko Kudo and colleagues from the Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University have published the article: Review began 11/07/2024 Review ended 12/02/2024 Published 12/06/2024 © Copyright, in the Journal: (JOURNAL) of December/06,/2024
  • How: These results . . .

     

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