Induced expression of ccl19 promotes the anti-tumor ability of car-t cells by increasing their infiltration ability

HIGHLIGHTS

• who: Jian-fei Hu and colleagues from the Jinan University, China have published the Article: Induced expression of CCL19 promotes the anti-tumor ability of CAR-T cells by increasing their infiltration ability, in the Journal: (JOURNAL)
• what: The authors designed a CAR-T targeting mesothelincoexpressing CCL19 downstream of an inducible expression system regulated by NFAT signaling.
• how: The results showed that neither the addition of CCL19 nor the overexpression of CCL19 could increase the rate of T_cell division .

SUMMARY

Physiologically CCL19 is expressed in the T zones in . . .

 



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