Induced pluripotent stem cells and genome-editing tools in determining gene function and therapy for inherited retinal disorders

HIGHLIGHTS

  • who: Daniela Benati and collaborators from the Centre for Regenerative Medicine, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy have published the research work: Induced Pluripotent Stem Cells and Genome-Editing Tools in Determining Gene Function and Therapy for Inherited Retinal Disorders, in the Journal: (JOURNAL)
  • what: As HDR activation is mostly restricted to S/G2 stages of the replication cycle , this approach has only been effective on actively dividing cells, which naturally extends to iPSC lines.

SUMMARY

    Since large amounts of embryonic tissue are required to . . .

     

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