Inducing respiratory complex i impairment elicits an increase in pgc1α in ovarian cancer

HIGHLIGHTS

• who: Monica De Luise from the DepartmentUniversity of have published the paper: Inducing respiratory complex I impairment elicits an increase in PGC1u03b1 in ovarian cancer, in the Journal: Scientific Reports Scientific Reports of 10/Dec/2021
• what: The authors show here that inhibition of CI triggers a compensatory response increasing PGC1u03b1 expression, which has not been shown thus far. The authors report that an increase in PGC1u03b1 is associated with augmented levels of specific PGC1u03b1 target genes involved in different pathways, such as mitochondrial energy metabolism, angiogenesis and lipid catabolism.
• how: The authors . . .
  

   

  

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