Induction of a disintegrin and metalloproteinase with thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent alzheimer`s disease risk

HIGHLIGHTS

• who: Qi Xu from the Shanghai University, China have published the article: Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-u03b2 and consequent Alzheimer`s disease risk, in the Journal: (JOURNAL)
• how: The sequencing data were compared with records of NCBI to search for potential single nucleotide polymorphisms (SNPs). Western blot data showed that the introduction of ADAMTS1 resulted in a novel APP hydrolysate accompanying traditionally recognized ones . Collectively the data indicated that ADAMTS1 and BACE1 competed for the same substrate.

 

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