Induction of neural differentiation and protection by a novel slow-release nanoparticle estrogen construct in a rat model of spinal cord injury

HIGHLIGHTS

• What: The authors have developed a novel slow-release NP estrogen (SNP-E2) delivery system that shows sustained release of E2 in the injured spinal cord and no systemic exposure in the host. While this study is focused on the slow-release nanoparticle (NP) estrogen (SNP-E2) construct, the overall goal is to co-administer the slow-release nano-E2 (SNP-E2) which may increase availability of E2 and prolong the therapeutic effects of FNP-E2 to decrease inflammation in subacute and chronic phases of the SCI. This study is focused on SNP-E2. This study showed . . .
  

   

  

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