Induction of tolerance to therapeutic proteins with antigen-processing independent t cell epitopes: controlling immune responses to biologics

HIGHLIGHTS

  • who: Evelien Schurgers from the Apitope International NV, Diepenbeek, Belgium, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom have published the research: Induction of Tolerance to Therapeutic Proteins With Antigen-Processing Independent T Cell Epitopes: Controlling Immune Responses to Biologics, in the Journal: (JOURNAL)
  • what: Based on the analysis of the mechanism of action of model apitope peptides, the authors have designed an ‘in patient' dose escalation protocol that optimises the generation of Treg cells . The approach has been to identify pan-DR binding epitopes expected to function in a wide range . . .

     

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