HIGHLIGHTS
- who: Haixia Zhuang from the (UNIVERSITY) have published the research work: Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia, in the Journal: (JOURNAL) of June/16,/2022
- what: The authors determine that when the RING domain is deleted (ΔRING) or the core cysteine residues in the zinc_finger are mutated (C632S/C635S), the WT protein, but not the ΔRING or mutant RNF6 protein, undergoes polyubiquitination. The authors show that USP7 interacts with RNF6 and abolishes its K48-linked polyubiquitination, thereby preventing its degradation. The authors demonstrate the . . .
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