Infection-induced membrane ruffling initiates danger and immune signaling via the mechanosensor piezo1

HIGHLIGHTS

  • who: Lalitha Tadala from the LaboratoryUmeau030a University Hospital, Aalborg, Denmark have published the research: Infection-induced membrane ruffling initiates danger and immune signaling via the mechanosensor PIEZO1, in the Journal: Microorganisms are generally sensed by receptors recognizing microbial molecules, which evoke changes in
  • what: The authors show that inherently mechanosensitive channel PIEZO1 acts as sensor for bacterial entry. The authors show that the formation of plasma_membrane ruffles accompanying the invasion of Gram-negative or Gram-positive bacteria is a physical immune signal of infection, which is detected by the mechanosensor PIEZO1. The authors focused the . . .

     

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