HIGHLIGHTS
- who: Irene M. Kaplow from the Department of Computational Biology, Carnegie Mellon University, Pittsburgh, PA, USA have published the research: Inferring mammalian tissue-specific regulatory conservation by predicting tissue-specific differences in open chromatin, in the Journal: (JOURNAL)
- what: The authors present criteria for systematically evaluating model performance for this task and use them to demonstrate that the models accurately predict tissue-specific conservation and divergence in open chromatin between primate and rodent species vastly outperforming leading nucleotide alignment-based approaches. 500 bp is the approximate resolution of open chromatin, shorter regions help the model . . .
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