HIGHLIGHTS
SUMMARY
Indeed, age-related features such as cellular senescence, oxidative stress, mitochondrial dysfunction, reduced numbers and regenerating capacity of satellite cells, adipose_tissue accumulation, inadequate nutrition, hormonal and cytokine changes all play a strong role in the development of sarcopenia. Mammalian regeneration of skeletal muscle is mediated by muscle stem_cells (MuSCs), also called satellite cells, the primary stem_cells of adult skeletal muscle. In another study, an increase in M2 macrophages during aging is associated with increased intermuscular adipose_tissue and impairment of muscle metabolism. Adipose tissue macrophages generate cytokines that promote insulin resistance and muscle atrophy and . . .
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