HIGHLIGHTS
SUMMARY
Innate anti-tumor immunity relies on classically activated (N1) neutrophils and macrophages (M1), natural killer (NK) cells, natural killer T (NKT) cells, and γ/δ T_cells. NKT_cells use NK surface receptors and the invariant CD1d-restricted T-cell receptor (TCR) to recognize glycolipids, while γδ T_cells recognize tumor-derived phosphoantigens or stress ligands by engaging semi-invariant γ/δ TCR. Adaptive anti-tumor immunity is principally based on mature dendritic cells (DCs), macrophages, tumor-specific CD4+ T helper 1 cells (Th1), CD8+ cytotoxic T_cells (CTLs), and cytotoxic antibody (Ab)-producing B cells. In this paradigm, professional antigen (Ag), presenting . . .
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