Inflammatory cytokines that enhance antigen responsiveness of naïve cd8+ t lymphocytes modulate chromatin accessibility of genes impacted by antigen stimulation

HIGHLIGHTS

  • who: Akouavi Julite Irmine Quenum et al. from the Department of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Universitu00e9 de Sherbrooke, Sherbrooke, QC J H , Canada have published the research: Inflammatory Cytokines That Enhance Antigen Responsiveness of Nau00efve CD8+ T Lymphocytes Modulate Chromatin Accessibility of Genes Impacted by Antigen Stimulation, in the Journal: (JOURNAL)
  • what: The authors show that cytokine priming modulates chromatin accessibility in a manner similar to Ag stimulation at several key genetic loci that harbor genes implicated in T_cell activation, effector differentiation, negative regulation and exhaustion.

SUMMARY . . .

 

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