HIGHLIGHTS
- who: Stefan Milde from the (UNIVERSITY) have published the paper: Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y, in the Journal: (JOURNAL)
- what: The work described here seeks to determine whether the inflammatory neuronal loss induced by peripheral LPS can be prevented by blocking the microglial P2Y6 receptor.
SUMMARY
To help elucidate mechanisms in_vitro, the authors co-cultured BV-2 microglia with differentiated PC12 dopaminergic neurons, and found that LPS induced microglial phagocytosis of neurons, which was prevented by a specific . . .
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