Inflammo-immune perspective on the association of eight migraine risk factors with migraine: a multi-omics mendelian randomization study

HIGHLIGHTS

• What: The authors utilized extensive genome-wide association studies (GWAS) summary statistics to assess the interconnections among 91 circulating inflammatory proteins, 731 immune cells, and the occurrence of migraines triggered by eight specific factors. The authors assess the strength of the instrumental variable using the F-statistic, with >10 indicating strong association (F=R2(n-k-1)/k(1-R2), n=sample size, R2 was estimated by minor allele frequency (MAF) and β value: R2=2 × MAF × (1-MAF) × β2) . The authors conducted three MR analyses. By examining the associations among these different factors, the authors aimed to . . .
  

   

  

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