HIGHLIGHTS
SUMMARY
The interaction of CB[n] with immunocompetent cells are challenges to be faced before achieving the practical aim of clinical applications, because the immune system is complex, multifactorial, multidimensional and self-regulating system. Indeed, today, it is known that CB[n] can across the cell membrane, which means that, theoretically, they may be interacted with any elements inside the cell, including cellular organelles such as mitochondria. The conventional levels (maybe low or moderate dosages) of ROS are necessary to perform B-cells functions; for example, switching the dormant state of cells and recirculation to . . .
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