HIGHLIGHTS
SUMMARY
For safe application of nanoparticles (NPs) in_vivo, it is important to fully understand their fate in the organism from the moment of their administration to complete decomposition and elimination from the body. Various strategies were designed to slowdown degradation of magnetic nanoparticles, for example coating of magnetite cores with gold shell, dense polystyrene or with highly chelating polyacrylic acid, as well as clustering of nanoparticles on the cell membrane prior their uptake. Understanding the biodegradation rate of magnetic nanoparticles, as well as subsequent increasing of the level of iron-containing metabolites in_vivo is important . . .
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