Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia

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SUMMARY

    Ischemic stroke is a leading cause of death and disability worldwide. With this background, the authors aimed to explore proteomic and transcriptomic changes at a brain level triggered during the hyperacute phase of cerebral ischemia in mice of four different groups: young male mice, young female mice, aged male mice and_(4) diabetic young male mice. The study consists of a discovery study performed on RNA and protein extracts from mice ischemic brains of four different groups: young male mice, young female mice, aged male mice and_(4) diabetic young male mice, using mass . . .

     

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