Inhibiting myostatin signaling partially mitigates structural and functional adaptations to hindlimb suspension in mice

HIGHLIGHTS

  • who: Andrea M. Hanson from the Published in cooperation with the Biodesign Institute at Arizona State University, with the support of NASA have published the paper: Inhibiting myostatin signaling partially mitigates structural and functional adaptations to hindlimb suspension in mice, in the Journal: (JOURNAL)
  • what: The authors used a highly specific anti-myostatin peptibody inhibitor of myostatin to evaluate the role of myostatin signaling in hindlimb suspension muscle pathology.
  • how: Group-wise comparisons showed that in vehicle-treated mice (HS-P) suspension significantly reduced hindlimb force by -19.8% (p and amplt 0 . . .

     

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