Inhibition of akt induces p53/sirt6/parp1-dependent parthanatos to suppress tumor growth

HIGHLIGHTS

• who: Yizheng Zhang from the Department of Health Management, The Third Xiangya Hospital, Central South University, Changsha, China have published the paper: Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth, in the Journal: (JOURNAL)
• what: The authors investigated whether AKT pathway takes part in non-apoptotic cell death in human CRC and the occurrence of parthanatos was observed. The authors identified that inhibiting AKT could trigger parthanatos thus leading to colon cancer growth suppression.
• how: After treating HCT116 cells with SC66 and Z-VAD-FMK the authors detected . . .
  

   

  

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