Inhibition of drp1–filamin protein complex prevents hepatic lipid droplet accumulation by increasing mitochondria–lipid droplet contact

HIGHLIGHTS

• What: The authors seek to understand whether the Drp1-FLNA protein complex is involved in hepatic LD accumulation caused by a high-fat diet (HFD) and whether cilnidipine and its derivative, 1,4-DHP, which only lacks Ca2+ channel-blocking action of cilnidipine, has therapeutic potency with respect to fatty liver in obese mice. The authors showed that excessive fat accumulation occurs in ob/ob mice and HFD-fed mice.
• Who: Kohei Ariyoshi and collaborators from the Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Sciences (NINS), Okazaki, Japan have published the Article . . .
  

   

  

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