Inhibition of e. coli recq helicase activity by structurally distinct dna lesions: structure—function relationships

HIGHLIGHTS

• who: Ana H. Sales and colleagues from the Chemistry Department, New York University, Washington Place, New York, NY, USA have published the research: Inhibition of E. coli RecQ Helicase Activity by Structurally Distinct DNA Lesions: Structureu2014Function Relationships, in the Journal: (JOURNAL)
• what: The aim of this work was to gain new insights into the relationships between the chemical structures of different DNA lesions, their conformations in double-stranded DNA, and their impact on helicase unwinding rates and efficiencies. The authors used kinetic methods to determine the shapes of the unwinding curves and the unwinding rate . . .
  

   

  

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