HIGHLIGHTS
- who: Liangliang Zhang and colleagues from the Institute Comparative Medicine, College Veterinary Medicine, Yangzhou University, Yangzhou , have published the paper: Inhibition of EZH2 Causes Retrotransposon Derepression and Immune Activation in Porcine Lung Alveolar Macrophages, in the Journal: (JOURNAL)
- what: The authors determined the global transcriptomic and epigenomic alterations in AMs after EZH2 inhibition using porcine 3D4/21 AM cells as a model, focusing on the coinciding immune activation and retrotransposon derepression, and the influence on viral infection. The study demonstrates that the inhibition of EZH2 causes the transcriptional activation of hundreds of innate immune genes . . .
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