Inhibition of ezh2 induces nk cell-mediated differentiation and death in muscle-invasive bladder cancer

HIGHLIGHTS

• who: Swathi Ramakrishnan from the Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA have published the Article: Inhibition of EZH2 induces NK cell-mediated differentiation and death in muscle-invasive bladder cancer, in the Journal: (JOURNAL)
• what: The authors provide evidence that alterations in chromatin modifying enzymes including KDM6A and members of the SWI/SNF complex are frequent in muscle-invasive bladder cancer. The authors show that EZH2 inhibition is most effective in bladder cancer cells with both SWI/SNF family member and KDM6A mutations, and is capable of augmenting cisplatin response . . .
  

   

  

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