Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression

HIGHLIGHTS

• who: Aoyuan Fan from the (UNIVERSITY) have published the research work: Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression, in the Journal: (JOURNAL) of 19/01/2022
• what: Since synoviocytes do not infiltrate the cartilage matrix in OA the authors reason that the soluble form of Fap secreted from OA synovium contributes to Col II degradation, which was confirmed by the ELISA analysis (Supplementary Fig 6b). Previous studies showed that Fap degrades denatured Col I35,63 as well as MMP1-cleaved native Col I.64,65 Here, the authors provide evidence . . .
  

   

  

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