HIGHLIGHTS
SUMMARY
Metabotropic glutamate receptor type 3 (mGluR3s; encoded by GRM3) signaling is increasingly linked to higher cognition in humans. mGluR3s differ from other glutamate receptors in that they are stimulated not only by glutamate, but also by NAAG (Nacetylaspartylglutamate), which is co-released with glutamate, (as well as with other neurotransmitters, e_g acetylcholine ), and is selective for mGluR3 (Fig 1A, B). NAAG levels are also decreased in vulnerable brain regions in patients with Alzheimer`s Disease (AD), and reduced NAAG levels correlated with cognitive deficits in multiple_sclerosis. As layer III dlPFC is a focus of . . .
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