Inhibition of histone deacetylase 6 suppresses inflammatory responses and invasiveness of fibroblast-like-synoviocytes in inflammatory arthritis

HIGHLIGHTS

  • who: Jin Kyun Park from the College of Medicine have published the article: Inhibition of histone deacetylase 6 suppresses inflammatory responses and invasiveness of fibroblast-like-synoviocytes in inflammatory arthritis, in the Journal: (JOURNAL)
  • what: The authors provide new evidence that HDAC6 regulates tissue-destructive RA-FLS via multiple mechanisms.
  • how: The results of the experiments were compared using t-tests.
  • future: Studies are needed to investigate the mechanisms (i.e. hyper- and deacetylation of cytoskeletal proteins such as tubulin impacts) by which HDAC6 (or its inhibition) affect cytoskeletal (re)organization . . .

     

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