Inhibition of histone methyltransferase smyd3 rescues nmdar and cognitive deficits in a tauopathy mouse model

HIGHLIGHTS

• who: Jamal B. Williams from the Animals, Human Postmortem Tissues, and Compounds Animal experiments were performed with the approval of the State University of New York at Buffalo Animal Care Committee (Protocol number:, )Tau mice used were from the , line, containing the , isoform of microtubule-associated protein tau with one, terminal insert and four microtubule binding repeats ( N R) encoding the human P S mutation, which was expressed under the Prnp promoter24. These mice were obtained from Jackson Laboratories with the genetic background (C BL/, u00d7 C H), bred (noncarrier u00d7 hemizygote), and genotyped via PCR from . . .
  

   

  

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