HIGHLIGHTS
- who: Irina Balan from the Midwestern University, United States have published the article: Inhibition of human macrophage activation via pregnane neurosteroid interactions with toll-like receptors: Sex differences and structural requirements, in the Journal: (JOURNAL)
- what: The authors examine the effect of allopregnanolone as well as the endogenous neurosteroid (3a,5a)-3,21dihydroxypregnan-20-one (3a,5a-THDOC) and a synthetic analog of allopregnanolone, SGE-516, on cultured human monocyte-derived macrophages (hMDM), obtained from both male and female healthy donors. The authors demonstrate unique inhibitory effects of allopregnanolone on the modulation of proinflammatory MyD88 . . .
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