Inhibition of mitochondrial complex ii by the anticancer agent lonidamine*

HIGHLIGHTS

• who: Lili Guo from the (UNIVERSITY) have published the Article: Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine*, in the Journal: (JOURNAL) of October/30,/2015
• what: The analysis showed that glutaminolysis flux was significantly higher in LND- and TTFA-treated cells (Fig 7G). Because LND effectively inhibits the SQR activity of complex II, the authors propose that LND inhibits complex II by interfering with the reduction of ubiquinone.
• how: In the SQR activity assay isolated mouse liver mitochondria were incubated with succinate and decylubiquinone together with 46 JOURNAL OF BIOLOGICAL . . .
  

   

  

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