Inhibition of neddylation suppresses osteoclast differentiation and function in vitro and alleviates osteoporosis in vivo

HIGHLIGHTS

  • who: Meng-Huang Wu and colleagues from the Department of Orthopaedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan have published the article: Inhibition of Neddylation Suppresses Osteoclast Differentiation and Function In Vitro and Alleviates Osteoporosis In Vivo, in the Journal: Biomedicines 2022, 10, 2355. of /2022/
  • what: The authors investigated the role and therapeutic potential of sRANKL-activated neddylation during osteoclast differentiation and osteoporosis both in_vitro and in_vivo. This study has some limitations, which include an OVX/sRANKL-induced osteoporosis model that might undergo a rapid bone loss compared with the . . .

     

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