HIGHLIGHTS
- who: Peptides et al. from the , Germany, School of Biological Sciences, Nanyang Technological University have published the article: Inhibition of Nutlin-Resistant HDM2 Mutants by Stapled Peptides, in the Journal: PLOS ONE | www.plosone.org of November/20,/2013
- what: In the present communication the authors show that stapled targeting the same region of HDM2 as Nutlin are refractory to these mutations and display reduced discrimination between the wild-type and mutant HDM2s with regards to functional abrogation of interaction with p53. The authors have demonstrated that stapled p53-peptide analogues can function in cells . . .
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