Inhibition of o-glcnacase leads to elevation of o-glcnac tau and reduction of tauopathy and cerebrospinal fluid tau in rtg4510 mice

HIGHLIGHTS

• who: Nicholas B. Hastings from the Discovery Chemistry Merck Research Laboratories, Kenilworth, NJ, USA have published the research work: Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice, in the Journal: (JOURNAL)
• what: This study shows that chronic inhibition of OGA reduces pathological tau in the brain and total tau in the CSF of rTg4510 mice most likely by directly increasing O-GlcNAcylation of tau and thereby maintaining tau in the soluble non-toxic form by reducing tau aggregation and the accompanying . . .
  

   

  

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